Leu HB, Chung CM, Lin SJ, Chiang KM, Yang HC, Ho HY, Ting CT, Lin TH, Sheu SH, Tsai WC, Chen JH, Yin WH, Chiu TY, Chen CI, Fann CS, Chen YT, Pan WH, Chen JW. Hypertens Res. 2015 Feb;38(2):155-62.
To establish the relationship between circadian rhythms and cardiovascular health, a study of 372 young hypertensives was performed, in which SNPs in the circadian genes bmal1 (rs3816358), per2 (rs6431590), npas2 (rs3888170), ror-α (rs10519096) and β (rs1410225) were shown to be predictive of non-dipping hypertension (as measured via ambulatory blood pressure). A second cohort of 619 young-onset hypertensives were then assessed, and confirmed the genetic association.
The SNPs are found in: