REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American

Garaulet M, Smith CE, Gomez-Abellán P, Ordovás-Montañés M, Lee YC, Parnell LD, Arnett DK, Ordovás JM. Mol Nutr Food Res. 2014 Apr;58(4):821-9.

To determine the role of SNPs in metabolic disease, a study of 810 North American and 1404 Spanish Mediterranean subjects was performed. Subjects had blood, anthropometrics, dietary intake (via Diet History Questionnaire) and physical activity (via International Physical Activity Questionnaire) assessed to determine metabolic status. 

The authors found that carriers of the minor alleles of a SNP (rs2314339) in rev-erb-α were less likely to be obese, had more daily and weekly physical activity, and lower waist circumference. The study also investigated the association between the SNP and diet, but no significant findings were replicated in both populations

rs2314339 in rev-erb-α

reverba rs2314339

NCBI Variation Viewer rs2314339


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