Two new rare variants in the circadian “clock” gene may influence sleep pattern

Pirovano A, Lorenzi C, Serretti A, Ploia C, Landoni S, Catalano M, Smeraldi E and Lorenzi C. Genetics in Medicine. 2005;7: 455–457.

To confirm the role of clock SNPs in mood disorders, an Italian study was performed, and a rare clock gene SNP was found to only be present in those with mood disorders. None of the 76 healthy controls and 2 of the 1037 ill patients had this rare mutation.

These patients both had disturbed sleep schedules and difficulty maintaining consistent daily rhythms. However, a statistical analysis was not performed to estimate the size of the mutation’s effect or to determine whether the results were simply due to variability.

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