Circadian Clock-Related Polymorphisms in Seasonal Affective Disorder and their Relevance to Diurnal Preference

Johansson C, Willeit M, Smedh C, Ekholm J, Paunio T, Kieseppä T, Lichtermann D, Praschak-Rieder N, Neumeister A, Nilsson L, Kasper S, Peltonen L, Adolfsson R, Schalling M and Partonen T. Neuropsychopharmacology. 2003;28:734–739.

To discover the relationship between circadian genes and mood disorders, investigators recruited Europeans with (n=159) and without (n=159) seasonal affective disorder (SAD, as diagnosed by the Seasonal Pattern Assessment Questionnaire ) for a case control study to assess the relationship between SAD and SNPs at clock and npas2  gene loci.

They found that Europeans with SAD were more likely to have SNPs in the npas2 gene than healthy controls; additionally, the Gly allele of the per3 647 Val/Gly mutation was found to be associated with morning preference.

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