Circadian Polymorphisms in Night Owls, in Bipolars, and in Non-24-Hour Sleep Cycles

Kripke D, Klimecki W, Nievergelt C, Rex K, Murray S, Shekhtman T, Tranah G, Loving R, Lee H, Rhee M, Shadan F, Poceta J, Jamil S, Kline L and Kelsoe J. Psychiatry Investig. 2014 Oct; 11(4): 345–362.

To determine potential causes of delayed sleep phase syndrome (DSPS), a disease where patients have difficulty falling asleep at night and arising in the morning, a study performed in 826 people from the United States found that 2 SNPs are associated with DSPS. The two SNPs are rs2482705 SNP in nfil3 and the rs3828057 SNP in ror-c. 

rs2482705 in nfil3

nfil3 rs2482705

NCBI Variation Viewer rs2482705

rs3828057 on ror-c

ror-c rs3828057

NCBI Variation Viewer rs3828057


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