Clock-cancer connection in Non-Hodgkin’s Lymphoma: a genetic association study and pathway analysis of the circadian gene Cryptochrome 2

Hoffman A, Zheng T, Stevens R, Ba Y, Zhang Y, Leaderer D, Yi C,  Holford T and Zhu Y. Cancer Res. 2009 Apr 15; 69(8): 3605–3613.

To assess potential genetic causes of cancer, a genetic association study was performed in women from Connecticut to search for SNPs associated with Non-Hodgkin’s Lymphoma (NHL). Subjects were recruited from Yale’s Cancer Centrerandomly dialed or using health care financing records.

 After adjusting for age, race, and family history of cancer, several SNPs in the cry2 gene were found to be associated with histologically confirmed NHL. The study also investigated the mechanisms by which the SNPs (rs11038689, rs7123390, and rs1401417) affected immune and hematologic pathways.

The SNPs in the cry2 gene:

cry2 rs11038689, rs7123390, and rs1401417

NCBI Variation Viewer rs11038689-rs7123390-rs1401417

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