Zhou F, He X, Liu H, Zhu Y, Jin T, Chen C, Qu F, Li Y, Bao G, Chen Z and Xing J. Cancer. 2012; 118(4): 937–946.
To determine the relationship between the cancer and circadian genes, a case-control study of 496 Chinese patients with resected colorectal cancer was performed. It found that patients with the clock rs3749474 SNP had increased survival than those with the wild type allele, after adjusting for age, sex, tumor position, stage, differentiation, and chemotherapy.
rs3749474 SNP in clock