Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder

Lee KY, Song JY, Kim SH, Kim SC, Joo EJ, Ahn YM, Kim YS. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct; 34 (7): 1196–1201.

A study of 610 Koreans  was performed to determine whether circadian preferences and bipolar disorder can be influenced by genetics. It found a significant positive association between the rs1801260 SNP in the clock gene and bipolar disorder. The authors also discovered a trending but not significant relationship between this SNP and extreme morning or evening chronotype as measured by the Composite Scale of Morningness questionnaire.

rs1801260 in clock

 Clock rs1801260

NCBI Variation Viewer rs1801260

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