The clock (Circadian Locomotor Output Cycles Kaput) gene is central to the clock mechanism. In short, CLOCK dimerizes with another circadian protein BMAL1 and the complex binds to the E-box element of the promotor region in many genes, and induces their transcription. In this manner, it controls the expression of many genes, including others in the circadian system.
Using the negative feedback of the clock mechanism, CLOCK protein levels cycle about every 24 hours, leading to the genes that it controls to cycle. These ciradian rhythms in gene expression lead to clinically relevant circadian rhythms such as blood pressure and incidence of heart attacks.
The SNPs discussed on this blog are shown here:
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