PER2 rs2304672 Polymorphism Moderates Circadian-Relevant Reward Circuitry Activity in Adolescents

Forbes EE, Dahl RE, Almeida JR, Ferrell RE, Nimgaonkar VL, Mansour H, Sciarrillo SR, Holm SM, Rodriguez EE, and Phillips ML. Biol Psychiatry. 2012 Mar 1;71(5):451-7.

The purpose of this study of 90 adolescents was to determine the relationship between SNPs in circadian genes and reward mediating brain circuitry. The authors found that carriers of the G allele for the rs2304672 SNP in per2 tended to have less brain activity in the medial prefrontal cortex, an area of the brain associated with self-regulation, as measured by functional magnetic resonance imaging (fMRI).

rs2304672 in per2

per2 rs2304672
NCBI Variation Viewer rs2304672

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