Association of Tef polymorphism with depression in Parkinson disease.

Hua P, Liu W, Kuo SH, Zhao Y, Chen L, Zhang N, Wang C, Guo S, Wang L, Xiao H, Kwan JY, Wu T. Mov Disord. 2012 Nov;27(13):1694-7.

Parkinson’s disease patients tend to develop depression, and the authors of this paper assessed the role of circadian genetics in its pathogenesis. A genetic association study was performed in 408 Chinese patients with Parkinson’s Disease, and after adjusting for demographics, disease severity and treatment dose, the study found that the tef  SNP rs738499 is associated with symptoms of depression (via the Hamilton Rating Scale for Depression) in people with Parkinson’s Disease.

rs738499 in tef

tef rs738499

NCBI Variation Viewer rs738499


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