CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American.

Dashti HS, Smith CE, Lee YC, Parnell LD, Lai CQ, Arnett DK, Ordovás JM, Garaulet M. Chronobiol Int. 2014 Jun;31(5):660-7.

A study in 820 North Americans and 728 people living in the Mediterranean area was carried out to evaluate the role of genetics in insulin resistance. The subjects were recruited from weight loss clinics (Mediterranean) or from the Blood Institute Family Heart Study field centers (American), and measures of blood and diet via (Diet History Questionnaire or 24 hour recall) were recorded.

The author found that greater carbohydrate intake is associated with increased insulin resistance in Mediterraneans with the CC allele of cry1 SNP rs2287161 versus those with non-CC alleles. This effect was nearly significant in the North American population as well. Additionally, they found that the effect of carbohydrate intake on predicted insulin resistance was dependant on genotype.

rs2287161 in cry1

cry1 rs2287161

NCBI Variation Viewer rs2287161

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