A polymorphism at the 3′-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder.

Kissling C, Retz W, Wiemann S, Coogan AN, Clement RM, Hünnerkopf R, Conner AC, Freitag CM, Rösler M, Thome J. Am J Med Genet B Neuropsychiatr Genet. 2008 Apr 5;147(3):333-8.

The purpose of this study was to assess the relationship between SNPs in the clock gene and adult attention-deficit hyperactivity disorder (ADHD). The study included 143 German men aged 31.3 ± 11.7 (mean ± standard deviation), who were genotyped for SNPs via blood samples and ADHD status was assessed by self report followed by the WenderReimherr diagnostic interview.

A SNP in the clock gene (rs1801260) was found to be associated with ADHD by non-parametric analysis of covariance, adjusting for age, presence of personality disorders and multiple comparisons. Compared to those homozygous for the C/C alleles, those homozygous for the T/T allele had higher scores on measures of ADHD.

rs1801260 in clock

Clock rs1801260

NCBI Variation Viewer rs1801260

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