SIRT1 gene is associated with major depressive disorder in the Japanese population.

Kishi T, Yoshimura R, Kitajima T, Okochi T, Okumura T, Tsunoka T, Yamanouchi Y, Kinoshita Y, Kawashima K, Fukuo Y, Naitoh H, Umene-Nakano W, Inada T, Nakamura J, Ozaki N, Iwata N. J Affect Disord. 2010 Oct;126(1-2):167-73.

Given the many studies of circadian genes and mood disorders, the authors investigated sirt1 SNPs as mediators of the pathogenesis of Hamilton Rating Scale for Depression diagnosed major depressive disorder (MDD). The study of 450 Japanese people with MDD and 766 healthy controls working in hospitals found that a sirt1 gene SNP (rs10997875) is associated with MDD. The authors also tested for a gene-anti-depressant interaction, but the association was not significant.

rs10997875 in sirt1

sirt1 rs10997875

NCBI Variation Viewer rs10997875

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