Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.

Utge SJ, Soronen P, Loukola A, Kronholm E, Ollila HM, Pirkola S, Porkka-Heiskanen T, Partonen T, Paunio T. PLoS One. 2010 Feb 18;5(2):e9259.

Building on previous work in which several genes were found to be associated with depression, a Finnish study of 1654 people (384 people with depression and 1270 controls as diagnosed via the Composite International Diagnostic Interview) found that females with the timeless SNPs rs7486220, rs2291739, rs2291738, and rs1082214 and males with rs1082214 and rs7486220 were more likely to be depressed than those who do not.

Additionally, the authors found rs1082214-associated seasonal changes in mood, sleep duration, energy level and social activity in women as well as morning preference and fatigue in men.

The SNPs in timeless

Timeless rs2291739-rs2291738-rs7486220-rs1082214

NCBI Variation Viewer rs2291739-rs2291738-rs7486220-rs1082214

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