Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.

Soria V, Martínez-Amorós E, Escaramís G, Valero J, Pérez-Egea R, García C, Gutiérrez-Zotes A, Puigdemont D, Bayés M, Crespo JM, Martorell L, Vilella E, Labad A, Vallejo J, Pérez V, Menchón JM, Estivill X, Gratacòs M, Urretavizcaya M. Neuropsychopharmacology. 2010 May;35(6):1279-89.

To explore the hypothesis of circadian disruption mediating vulnerability to depression, a study of 534 people with mood disorders and 440 controls from a Caucasian Spanish population analyzed more than 200 SNPs in circadian genes found several SNPs in multiple genes that are associated with major depressive disorder.

After adjusting for multiple comparisons, the cry1 SNP rs2287161 as well as an additive effect of rs2287161 in cry1 and rs11123857 in npas2 were found to be significantly associated with major depressive disorder (as diagnosed via Diagnostic and Statistical Manual of Mental Disorders IV criteria).

rs2287161 in cry1

cry1 rs2287161

NCBI Variation Viewer rs2287161

rs11123857 in npas2

npas2 rs11123857
NCBI Variation Viewer rs11123857

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