Investigation of associations between NR1D1, RORA and RORB genes and bipolar disorder

Lai YC, Kao CF, Lu ML, Chen HC, Chen PY, Chen CH, Shen WW, Wu JY, Lu RB, Kuo PH. PLoS One. 2015 Mar 19;10(3):e0121245.

To investigate the relationship between circadian genetics and disease, the authors performed two studies consisting of 2698 members of the Chinese Han population. It was determined that several SNPs in reverb-α, ror-α and ror-β are associated with bipolar disorder, as determined by the Composite International Diagnostic Interview. After multiple comparison corrections, only rs4774388 in ror-α and rs1327836 in ror-β were still significantly associated with the disorder.

rs4774388 in ror-α

ror-a rs4774388

NCBI Variation Viewer rs4774388

rs1327836 in ror-β

ror-b rs1327836

NCBI Variation Viewer rs1327836

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s