Lai YC, Kao CF, Lu ML, Chen HC, Chen PY, Chen CH, Shen WW, Wu JY, Lu RB, Kuo PH. PLoS One. 2015 Mar 19;10(3):e0121245.
To investigate the relationship between circadian genetics and disease, the authors performed two studies consisting of 2698 members of the Chinese Han population. It was determined that several SNPs in reverb-α, ror-α and ror-β are associated with bipolar disorder, as determined by the Composite International Diagnostic Interview. After multiple comparison corrections, only rs4774388 in ror-α and rs1327836 in ror-β were still significantly associated with the disorder.
rs4774388 in ror-α
rs1327836 in ror-β