Suicidal behavior in the context of disrupted rhythmicity in bipolar disorder–data from an association study of suicide attempts with clock genes.

Pawlak J, Dmitrzak-Weglarz M, Maciukiewicz M, Wilkosc M, Leszczynska-Rodziewicz A, Zaremba D, Kapelski P, Hauser J. Psychiatry Res. 2015 Apr 30;226(2-3):517-20.

In order to explain the circadian rhythm present in suicide attempts, the authors investigated the relationships between SNPs in circadian genes and suicidal behaviour. A study of 863 bipolar patients from Poland determined that several SNPs on the clock (rs3805148 and rs534654) and timeless (rs11171856 and rs2291739) genes are associated with age of first attempt, violent suicide attempts, multiple suicide attempts, and a family history of suicide as determined by the Structured Clinical Interview for DSM-IV Axis I Disorders.

The SNPs in clock

clock rs3805148-rs534654

NCBI Variation Viewer rs3805148-rs534654

The SNPs in timeless

timeless rs11171856-rs2291739

NCBI Variation Viewer rs11171856-rs2291739

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