A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome.

Garcia-Rios A, Perez-Martinez P, Delgado-Lista J, Phillips CM, Gjelstad IM, Wright JW, Karlström B, Kiec-Wilk B, van Hees AM, Helal O, Polus A, Defoort C, Riserus U, Blaak EE, Lovegrove JA, Drevon CA, Roche HM, Lopez-Miranda J. J Nutr. 2012 Jul;142(7):1213-8

To assess genetic determinants of metabolic syndrome, this study investigated the association between common SNPs in per2 and plasma lipid metabolism in participants from the European LIPGENE study. The subjects were volunteers with metabolic syndrome recruited from eight European countries via general practitioner databases and advertisements. Subjects had their blood taken for lipid biomarker measurements and for SNP genotyping.

In patients with a high plasma saturated fatty acid (SFA) concentration, the minor allele for rs2304672 in the per2 gene was associated with increased concentrations of fasting plasma triglycerides, triglyceride-rich lipoprotein, apoC-II, apoC-III, and apoB-48 compared to those with the major CC allele. Conversely, carriers of the minor rs2304672 allele with low SFA concentrations had lower plasma concentrations of fasting triglycerides, cholesterol, triglyceride-rich lipoprotein, apoC-II, apoC-III, apoB, and apoB-48 compared to those with the major allele, thus demonstrating an interaction between per2 and lipid metabolism.

rs2304672 in per2

per2 rs2304672

NCBI Variation Viewer rs2304672

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