CLOCK gene variants associate with sleep duration in two independent populations.

Allebrandt KV, Teder-Laving M, Akyol M, Pichler I, Müller-Myhsok B, Pramstaller P, Merrow M, Meitinger T, Metspalu A, Roenneberg T. Biol Psychiatry. 2010 Jun 1;67(11):1040-7.


To investigate the relationship between sleep duration and clock gene polymorphisms, a pair of genetic association studies and a meta-analysis of the two were performed. The first association study was performed in 333 participants from Northern Italy who were recruited from the MICROS study. A second replication study was performed in participants recruited from the Estonian genome project who had very long (>8.5 hours) or very short (<7 hours) sleep durations, as determined by the Munich ChronoType Questionnaire. A meta-analysis of the results from each of the two populations found that the rs12649507 SNP in clock was associated with sleep duration and the rs12649507-rs11932595 GGAA clock haplotype was associated with long sleep duration.

rs12649507-rs11932595 in clock

clock rs12649507-rs11932595

NCBI Variation Viewer rs12649507-rs11932595

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