Chang YC, Chiu YF, Liu PH, Hee SW, Chang TJ, Jiang YD, Lee WJ, Lee PC, Kao HY, Hwang JJ, Chuang LM. PLoS One. 2013 Jul 26; 8(7): e69622.
This study assessed the associations between circadian SNPs and metabolic phenotypes in populations in Taiwan. Subjects were recruited from the Taipei Health Management Center of National Taiwan University Hospital and from a screening program in the Yunlin County. Blood pressure, fasting glucose and triglycerides were measured and a total of 20 SNPs were genotyped in these populations.
The authors found that the A allele at rs9684900 in the noc gene was significantly associated with higher body mass index (BMI). Additionally, higher fasting blood glucose was found in those with the A allele for rs135764 in the csnk1e gene. Other multi-locus interactions and joint effects of risk allelles were found to be associated with metabolic phenotypes, but were not significant after correcting for multiple comparisons.
To support their findings, the authors also assessed whether noc expression in adipose tissue was associated with obesity and found increased expression in subcutaneous and visceral fat in obese subjects.
rs9684900 in noc
rs135764 in csnk1e