Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature.

Dashti HS, Aslibekyan S, Scheer FA, Smith CE, Lamon-Fava S, Jacques P, Lai CQ, Tucker KL, Arnett DK, Ordovás JM. Am J Hypertens. 2015 Jun 4.

To assess the contribution of SNPs in Clock genes, the authors analyzed the data from 819 paarticipants of the Genetics of Lipid Lowering Drugs and Diet Network Study. Blood pressure and samples for genotyping were taken from each analyzed participant.

Using the Genome-Wide Complex Trait Analysis to assess the combined effect of 5004 SNPs in clock genes, the authors found that clock genes explained 7.1±3% of the total variability in systolic blood pressure. The genes were not found to be significantly associated with diastolic blood pressure, and an analysis of each SNP separately found no significant associations after correcting for multiple testing, and a replication study confirmed this result.


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