Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression.

Benedetti F, Dallaspezia S, Fulgosi MC, Lorenzi C, Serretti A, Barbini B, Colombo C, Smeraldi E. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5.

To elucidate the role of circadian SNPs in bipolar disorder (BD), a study in which 39 inpatients with DSV-IV diagnosed BD was performed. The subjects had their activity measured by wrist actigraphs and were genotyped for the rs1801260 SNP in clock.

It was determined that the carriers of the C allele of rs1801260 had higher activity at night, and that the effect of lithium on activity was mediated by genotype. These results, while statistically significant, were not adjusted for the multiple tests that were performed and may thus be false positives.

rs1801260 in clock

Clock rs1801260

NCBI Variation Viewer rs1801260

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