Breast cancer risk, nightwork, and circadian clock gene polymorphisms

Truong T, Liquet B, Menegaux F, Plancoulaine S, Laurent-Puig P, Mulot C, Cordina-Duverger E, Sanchez M, Arveux P, Kerbrat P, Richardson S, Guénel P. Endocr Relat Cancer. 2014 Aug;21(4):629-38.

In order to determine the role of SNPs in circadian genes in breast cancer, and whether these SNPs could mediate the effect of night shift work on risk of cancer, a case-control study was performed in which French women aged 25-75 with (n=1126) and without (n=1174) breast cancer gave buccal or blood samples. Participants were also interviewed to determine demographic, lifestyle, medical, and work history information.

In an analysis of 577 SNPs in circadian genes, rs1482057 and rs12914272 in ror-a were found to be associated with breast cancer after adjustment for several confounding variables and multiple testing. In post-menopausal women, these SNPs and rs11932595 in clock were found to be very nearly significantly associated with breast cancer, after adjustment. Tests for interaction between night shift work and SNPs were not significant after FDR post-hoc procedures

Additionally, a whole-gene analysis of SNPs found that the circadian pathway and clock  in particular were significantly associated with breast cancer only in post-menopausal women.

SNPs in ror-a

ror-a rs1482057-rs12914272

NCBI Variation Viewer rs1482057-rs12914272

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