Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population).

Garaulet M, Lee YC, Shen J, Parnell LD, Arnett DK, Tsai MY, Lai CQ, Ordovas JM. Eur J Hum Genet. 2010 Mar;18(3):364-9.

The aim of this study was to assess the role of clock in eating patterns and associated metabolic cytokines. The 1100 participants recruited from the Genetics of Lipid Lowering Drugs and Diet Network cohort were genotyped, filled out the Diet History Questionnaire, and gave blood samples for cytokine analysis.

It was determined that after adjusting for several confounders, carriers the minor alleles inclock SNPs rs3749474 and rs4580704 had lower and higher dietary energy intake respectively.

Additionally, rs3749474 was associated with the inflammatory cytokine monocyte chemotactic protein 1. Other associations were nominally significant, but were no longer significant after Bonferroni adjustment for multiple testing.

SNPs in clock

clock rs3749474-rs4580704-rs1801260

rs3749474-rs4580704-rs1801260

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