Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position.

Bandín C, Martinez-Nicolas A, Ordovás JM, Ros Lucas JA, Castell P, Silvente T, Madrid JA, Garaulet M. Int J Obes (Lond). 2013 Aug;37(8):1044-50.

In order to determine the role of the clock SNP rs1801260 in circadian disruption, a study was performed in 85 overweight/obese Spanish women. After recruitment from a previous study, the participants had body measures taken, blood drawn for genotyping and took the Horne and Ostberg chronotype questionnaire. Additionally, circadian rhythms of body position, activity and wrist temperature were measured by a pair of sensors attached to the patients’ non-dominant arm.

The authors found that carriers of the C allele of rs1801260 had circadian rhythms with lowered amplitude, power and robustness compared to the TT geneotype. In general, C allele carriers had higher wrist temperature, especially during the early morning and late evening. In all of the measures of circadian activity, the C carriers had less daily activity and were phase delayed compared to TT controls.

rs1801260 in clock

Clock rs1801260

NCBI Variation Viewer rs1801260

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