Evans DS, Parimi N, Nievergelt CM, Blackwell T, Redline S, Ancoli-Israel S, Orwoll ES, Cummings SR, Stone KL, Tranah GJ; Study of Osteoporotic Fractures (SOF); Osteoporotic Fractures in Men (MrOS) Study Group. Sleep. 2013 Mar 1;36(3):431-46
To determine the association between SNPs in circadian genes and sleep disturbances in the elderly, data was analyzed from 2 different cohort studies; the Study of Osteoporotic Fractures (SOF) and Osteoporotic Fractures in Men (MrOS). Participants were aged 65 or older, were genotyped and had their activity measured via wrist-mounted actigraphs.
It was determined that several SNPs were associated with many characteristics of sleep. In a meta analysis of both studies, rs1047776 in leprel2 and rs2238114 in usp5 are associated with wake after sleep onset, a measure of sleep quality. In the MrOS study, rs3816358 in bmal1, rs3768984 in npas2, and their interaction were found to be associated with sleep and wake timing. Finally, the SOF analysis found that rs895520 in npas2 and rs1047776 in leprel2 were associated with activity robustness and sleep latency respectively.
rs1047776 in leprel2
rs2238114 in usp5
rs3816358 in bmal1
rs3768984 and rs895520 in npas2